|
KMID : 0043319880110040266
|
|
Archives of Pharmacal Research
1988 Volume.11 No. 4 p.266 ~ p.269
|
|
|
Synthesis and Antimicrobial Activity of Some Indole Derivatives
|
|
Hishamt OH
Abdel Rahman AH/Nasef AMM/Ismail MMF/Abdel Hamid AHA
|
|
|
Abstract
|
|
|
|
Bromination of 2,3-diphenyl-5-methylindole (I) (using 3mol) with bromine gave the 4,6-dibromo derivative (II) which upon oxidation gave the corresponding 2-benzamido benzophenone derivative (III). Bromination (using 6mol) with bromine afforded the tetrabromo derivative (IVa) which reacted with amines to form the corresponding 5-substituted aminomethyl derivatives (IVb-d). Further bromination of II using only 1mol gave the tribromo derivative (Va) which in turn reacted with amines to form Vb-g. The antimicrobial activities of compounds I, IVa, IVc, Va, Ve, Vf and Vg were studied.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|